| 货号 | 2458/10 |
| 别名 | N-[4-[[6-Methoxy-7-[3-(4-morpholiny |
| 供应商 | Tocris |
| 生物活性 | Novel, selective ATP-competitive inhibitor of Aurora B kinase in vitro(IC50 values are 50, 250 and 1000 nM for Aurora B, C and A kinases respectively). Selective over a range of other kinases including cdk1 and PLK1 (IC50 > 10 μM). Inhibits cell division and displays selective toxicity towards proliferating tumor cells versus non-dividing cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 513.59 |
| 分子式 | C29H31N5O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 331771-20-1 |
| 参考文献 | Girdleret al (2006) Validating Aurora B as an anti-cancer drug target. J.Cell Sci. 119 3664. PMID: 16912073. Junget al (2006) Discovery of novel and potent thiazoloquinazolines as selective Aurora A and B kinase inhibitors. J.Med.Chem. 49 955. PMID: 16451062. Ditchfieldet al (2003) Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores. J.Cell Biol. 161 267. PMID: 12719470. |