| 货号 | 4630/10 |
| 别名 | 2-(4-Amino-1,2,5-oxadiazol-3-yl)-1- |
| 供应商 | Tocris |
| 生物活性 | Potent, ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor (IC50 = 11 nM in an in vitro kinase assay); targets the N-terminal kinase domain. Inhibits MSK1, MSK2, PKA, PKB, RSK and p70S6K activity in cells. Blocks IL-10 production in macrophages. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 415.32 |
| 分子式 | C16H22N8O.2HCl |
| 可溶性/溶解性 | Soluble to 50 mM in water and to 50 mM in DMSO |
| 参考文献 | Naqviet al (2012) Characterization of the cellular action of the MSK inhibitor SB-747651A. Biochem.J. 441 347. PMID: 21970321. Bamfordet al (2005) (1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: a novel class of potent MSK-1-inhibitors. Bioorg.Med.Chem.Lett. 15 3402. PMID: 15950465. Bamfordet al (2005) (1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: further optimisation as highly potent and selective MSK-1-inhibitors. Bioorg.Med.Chem.Lett. 15 3407. PMID: 15955699. |