| 货号 | 4278/10 |
| 别名 | N-Methyl-N-[2-[[[2-[(2,3-dihydro-2- |
| 供应商 | Tocris |
| 生物活性 | Dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Promotes osteoblast recruitment and activity, and stimulates bone formation in ovariectomized rats. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 506.5 |
| 分子式 | C22H21F3N6 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Allenet al (2010) Emerging targets in osteoporosis disease modification. J.Med.Chem. 53 4332. PMID: 20218623. Hanet al (2009) Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design. J.Biol.Chem. 284 13193. PMID: 19244237. Buckbinderet al (2007) Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis. Proc.Natl.Acad.Sci.USA 104 10619. PMID: 17537919. |