| 货号 | 2452/10 |
| 别名 | 5-[(1,1'-Biphenyl]-4-yl)methyl]-N,N- |
| 供应商 | Tocris |
| 生物活性 | Novel and highly potent blocker of anandamide uptake (IC50 = 270 pM). Inhibits fatty acid amide hydrolase (FAAH) activity (IC50 = 12.4 nM). Following i.p. administration in rats, increases brain anandamide concentration and exerts antinociceptive effects in formalin model of pain. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 307.35 |
| 分子式 | C17H17N5O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in ethanol with gentle warming |
| CAS号 | 874902-19-9 |
| 参考文献 | Alexander and Cravat (2006) The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases. J.Am.Chem.Soc. 128 9699. PMID: 16866524. Dickason-Chesterfieldet al (2006) Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors. Cell Mol.Neurobiol. 26 407. PMID: 16736384. Mooreet al (2005) Identification of a high-affinity binding site involved in the transport of endocannabinoids. Proc.Natl.Acad.Sci.USA 10217852. |