| 货号 | 4382/50 |
| 别名 | 4,4'-(1H-1,2,4-Triazol-1-ylmethylene |
| 供应商 | Tocris |
| 生物活性 | Potent, reversible non-steroidal aromatase inhibitor (IC50 = 11.5 nM). Displays antitumor effects in several animal models. Suppresses the endogenous aromatase-induced proliferation of MCF-7 cells. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 285.3 |
| 分子式 | C17H11N5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Bhatnagar (2007) The discovery and mechanism of action of letrozole. Breast Cancer Res.Treat. 105 7. PMID: 17912633. Mitropoulouet al (2003) Letrozole as a potent inhibitor of cell proliferation and expression of metalloproteinases (MMP-2 and MMP-9) by human epithelial breast cancer cells. Int.J.Cancer 104 155. PMID: 12569569. Bhatnagaret al (1990) Highly selective inhbition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor. J.Steroid Biochem.Mol.Biol. 37 1021. PMID: 2149502. |