KU 0063794 (10 MG)
货号：
3725/10 基本售价：
3648.5 元 规格：
10 mg
产品信息
概述| 货号 | 3725/10 |
| 别名 | rel-5-[2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol |
性能| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of mammalian target of rapamycin (mTOR) (IC50 ~10 nM for mTORC1 and mTORC2). Displays no activity at PI 3-kinase or 76 other kinases tested. Inhibits activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK. Suppresses cell growth and induces G1 cell cycle arrest in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >97 % |
| 计算分子量 | 465.54 |
| 分子式 | C25H31N5O4 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| CAS号 | 938440-64-3 |
| 参考文献 | Garcia-Martinezet al (2009) Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). Biochem.J. 421 29. PMID: 19402821. |
