EG 00229 (10 MG)
货号：
4931/10 基本售价：
3648.5 元 规格：
10 mg
产品信息
概述| 货号 | 4931/10 |
| 别名 | N2-[[3-[(2,1,3-Benzothiadiazol-4-ylsulfonyl)amino]-2-thienyl]carbonyl]-L-arginine |
性能| 供应商 | Tocris |
| 生物活性 | Neuropilin 1 (NRP1) receptor antagonist; inhibits VEGFA binding to the NRP1 b1 domain. Has no effect on VEGFA binding to VEGFR-1 and VEGFR-2. Reduces VEGFA-induced VEGFR-2 tyrosine phosphorylation in HUVECs. Also attenuates VEGFA-induced HUVEC cell migration and reduces A549 lung carcinoma cell viability in vitro. Increases chemo-sensitivity of A549 cells in combination with Taxol (Cat. No. 1097). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 497.57 |
| 分子式 | C17H19N7O5 |
| 可溶性/溶解性 | Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO |
| 参考文献 | Jarviset al (2010) Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J.Med.Chem. 53 2215. PMID: 20151671. |
