| 货号 | 4975/10 |
| 别名 | 2-[4-[[(2R)-2-aminobutyl]amino]-2-p |
| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of protein kinase D (PKD); inhibits all PKD isoforms (IC50 values are 1, 2 and 2.5 nM for PKD1, PKD3 and PKD2 respectively). Exhibits selectivity for PKD against a panel of >90 protein kinases, including PKCα, MEK, ERK, c-Raf and c-Src. Reduces proliferation and cell viability of pancreatic cancer cells expressing moderate levels of endogenous PKD1/2. Orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 411.33 |
| 分子式 | C18H22N6O.2HCl |
| 可溶性/溶解性 | Soluble to 20 mM in water and to 10 mM in DMSO |
| 参考文献 | Niet al (2013) PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors. PLoS ONE 9 e73149. PMID: 24039875. Harikumaret al (2010) A novel small molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitroandin vivo. Mol.Cancer Ther. 9 1136. PMID: 20442301. |