| 货号 | 16733-5mg |
| 描述 | 1-Azakenpaullone is an analog of kenpaullone (Item No. 10010239) that inhibits glycogen synthase kinase 3β (GSK3β) more potently (IC50 = 18 nM) than CDK1/cyclin B or CDK5/p25 (IC50s = 2.0 and 4.2 µM, respectively).1 Through its effects on GSK3β, 1-azakenpaullone stimulates the proliferation of human pancreatic islets and drives the differentiation of mouse embryonic stem cells and Nematostellalarvae.2,3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kunick, C.,Lauenroth, K.,Leost, M., et al. 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3β. Bioorganic & Medicinal Chemistry Letters 14(2), 413-416 (2004). 2.Liu, H.,Remedi, M.S.,Pappan, K.L., et al. Glycogen synthase kinase-3 and mammalian target of rapamycin pathways contribute to DNA synthesis, cell cycle progression, and proliferation in human islets. Diabetes 58(3), 663-672 (2009). 3.Mfopou, J.K.,Geeraerts, M.,Dejene, R., et al. Efficient definitive endoderm induction from mouse embryonic stem cell adherent cultures: A rapid screening model for differentiation studies. Stem Cell Res. 12(1), 166-177 (2014). 4.Marlow, H.,Matus, D.Q. and Martindale, M.Q. Ectopic activation of the canonical wnt signaling pathway affects ectodermal patterning along the primary axis during larval development in the anthozoan Nematostella vectensis. Dev.Biol. 380(2), 324-334 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 328.2 |
| 分子式 | C15H10BrN3O |
| CAS号 | 676596-65-9 |
| 稳定性 | ≥ 2 years |
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