| 货号 | 11495-25mg |
| 描述 | Receptors for VEGF have central roles in vasculogenesis and angiogenesis and thus serve as targets for cancer therapy.1,2 Cediranib is a potent inhibitor of VEGF receptor tyrosine kinases, including VEGFR1, 2, and 3 (IC50s = 5, 1, and 3 nM, respectively).3 It also potently inhibits a variety of other receptor and non-receptor tyrosine kinases, including several in the platelet-derived growth factor, fibroblast growth factor, and endothelial growth factor receptor families.3,4 Cediranib blocks tubule formation by human umbilical vein endothelial cells in vitro and prevents angiogenesis as well as xenograft tumor growth in vivo.3 Because of these effects, cediranib has potential use in a range of cancers.5,6,7 |
| 别名 | AZD 2171;Recentin™;ZD 2171; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Rini, B.I. Vascular endothelial growth factor-targeted therapy in metastatic renal cell carcinoma. Cancer 115(10 Suppl), 2306-2312 (2009). 2.Burger, R.A. Overview of anti-angiogenic agents in development for ovarian cancer. Gynecologic Oncology 121(1), 230-238 (2011). 3.Wedge, S.R.,Kendrew, J.,Hennequin, L.F., et al. AZD2171: A highly potent, orally bioavailable vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Research 65(10), 4389-4400 (2005). 4.Davis, M.I.,Hunt, J.P.,Herrgard, S., et al. Comprehensive analysis of kinase inhibitor selectivity. Nat.Biotechnol. 29(11), 1046-1051 (2011). 5.Bhargava, P., and Robinson, M.O. Development of second-generation VEGFR tyrosine kinase inhibitors: Current status. Curr.Oncol.Rep. 13(2), 103-111 (2011). 6.Conti, A.,Santoni, M.,Amantini, C., et al. Progress of molecular targeted therapies for advanced renal cell carcinoma. Biomed.Res.Int. 2013, 419176 (2013). 7.Castelli, C.,Tazzari, M.,Negri, T., et al. Structured myeloid cells and anti-angiogenic therapy in alveolar soft part sarcoma. Journal of Translational Medicine 11(1), 237 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 450.5 |
| 分子式 | C25H27FN4O3 |
| CAS号 | 288383-20-0 |
| 稳定性 | ≥ 2 years |
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