货号 | 17134-1mg |
描述 | Invariant, or type 1, natural killer T (NKT) cells can be activated when glycolipid antigens bind CD1d glycoproteins, which in turn present the glycolipids to T cell receptors. The cellular response depends on the structure of the glycolipid, with α-galactosyl ceramide (α-GalCer) initiating the release of a variety of cytokines.1 OCH is a sphingosine truncated analog of α-GalCer. Like α-GalCer, OCH stimulates NKT cells to produce Th2 cytokines, preventing diabetes and insulitis in non-obese diabetic mice.2 Specifically, OCH initiates preferential IL-4 production in NKT cells, and this can be converted to IFN-γ production by IL-12.3 The polarized production of Th2 cytokines in response to OCH has beneficial applications in autoimmune components of encephalomyelitis, multiple sclerosis, and type I diabetes.2,4 |
供应商 | Cayman |
应用文献 | |
1.Jervis, P.J.,Polzella, P.,Wojno, J., et al. Design, synthesis, and functional activity of labeled CD1d glycolipid agonists. Bioconjug.Chem. 24(4), 586-594 (2013). 2.Mizuno, M.,Masumura, M.,Tomi, C., et al. Synthetic glycolipid OCH prevents insulitis and diabetes in NOD mice. J.Autoimmun. 23, 293-300 (2004). 3.Oki, S.,Tomi, C.,Yamamura, T., et al. Preferential Th2 polarization by OCH is supported by incompetent NKT cell induction of CD40L and following production of inflammatory cytokines by bystander cells in vivo. International Immunology 17(12), 1619-1629 (2005). 4.Sullivan, B.A.,Nagarajan, N.A.,Wingender, G., et al. Mechanisms for glycolipid antigen-driven cytokine polarization by Vα14i NKT cells. Journal of Immunology 184(1), 141-153 (2010). | |
运输条件 | Wet ice in continental US; may vary elsewhere |
存放说明 | -20 |
纯度 | ≥95% |
计算分子量 | 704 |
分子式 | C39H77NO9 |
CAS号 | 383187-82-4 |
稳定性 | ≥ 2 years |
本官网所有报价均为常温或者蓝冰运输价格,如有产品需要干冰运输,需另外加收干冰运输费。 |