货号 | 5625/10 |
别名 | (1S,2R)-2-[[(1S)-1-[(1,3-Dihydro-1, |
供应商 | Tocris |
生物活性 | Nrf2 activator; inhibits Nrf2/Keap1 interaction (Kd = 1 μM). Promotes Nrf2 nuclear translocation and induces antioxidant response element (ARE) activity in vitro. Cell permeable. |
运输条件 | Blue Ice |
存放说明 | -20℃ |
纯度 | >98 % |
计算分子量 | 446.5 |
分子式 | C26H26N2O5 |
可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
参考文献 | Rosiniet al (2014) Oxidative stress in Alzheimer's disease: are we connecting the dots? J.Med.Chem. 57 2821. PMID: 24131448. Huet al (2013) Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction. Bioorg.Med.Chem.Lett. 23 3039. PMID: 23562243. |