| 货号 | 5563/10 |
| 别名 | MethylN-[2-[(R)-(3-Chlorophenyl)[(3R)-1-[ |
| 供应商 | Tocris |
| 生物活性 | Highly potent and selective renin inhibitor (IC50 = 0.47 nM). Displays >1000-fold selectivity over related and unrelated off-targets. Blocks renin-stimulated ERK1/2 phosphorylation in vascular smooth muscle cells. Exhibits a different mode of action to aliskiren (Cat. No. 5491). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >97 % |
| 计算分子量 | 639.1 |
| 分子式 | C26H41ClN4O5 |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| 参考文献 | Luet al (2014) Renin inhibitor VTP-27999 differs from aliskiren: focus on their intracellular accumulation and the (pro)renin receptor. J.Hypertens. 32 1255. PMID: 24637873. Jiaet al (2011) Discovery of VTP-27999, an alkyl amine renin inhibitor with potential for clinical utility. ACS Med.Chem.Lett. 2 747. PMID: 24900262. |