| 货号 | 5582/1 |
| 供应商 | Tocris |
| 生物活性 | Selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β(IC50 = 1.3 μM) . Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. Also reduces tubularization of hypoxic HUVECs. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 2559.1 |
| 分子式 | C111H188N42O |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | CLLFVY CGRKKRRQRRRPPQ* (Modifications: Lactam bridge: Cys-1 to Tyr-6), Disulfide bridge: 1-1*) |
| 参考文献 | Mirandaet al (2013) A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. J.Am.Chem.Soc. 135 10418. PMID: 23796364. |