| 货号 | 17803-1mg |
| 描述 | Voriconazole-d3 contains three deuterium atoms located on the β methyl group. It is intended for use as an internal standard for the quantification of voriconazole (Item No. 15633) by GC- or LC-mass spectrometry. Voriconazole is a triazole, antifungal agent that inhibits a broad range of pathogenic yeasts, including Candida (MIC = 0.03-8 µg/ml), and filamentous fungi such as Aspergillus,Scedosporium, and Fusarium.1,2 Its inhibitory action results from its ability to inhibit the synthesis of ergosterol, the major sterol of the fungal cell membrane.2,3,4 |
| 别名 | VRC-d3; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Herbrecht, R.,Nivoix, Y.,Fohrer, C., et al. Management of systemic fungal infections: Alternatives to itraconazole. J. Antimicrob. Chemother. 56(Suppl 1), i39-i48 (2005). 2.Delattin, N.,Cammue, B.P.A., and Thevissen, K. Reactive oxygen species-inducing antifungal agents and their activity against fungal biofilms. Future Med.Chem. 6(1), 77-90 (2014). 3.Munayyer, H.K.,Mann, P.A.,Chau, A.S., et al. Posaconazole is a potent inhibitor of sterol 14α-demethylation in yeasts and molds. Antimicrobial Agents and Chemotherapy 48(10), 3690-3696 (2004). 4.Warrilow, A.G.,Melo, N.,Martel, C.M., et al. Expression, purification, and characterization of Aspergillus fumigatus sterol 14-a demethylase (CYP51) isoenzymes A and B. Antimicrobial Agents and Chemotherapy 54(10), 4225-4234 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d3) |
| 计算分子量 | 352.3 |
| 分子式 | C16H11D3F3N5O |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |