| 货号 | 15138-100ug |
| 描述 | Nicotinamide N-Methyltransferase (NNMT) methylates nicotinamide and other pyridine containing compounds.1 NNMT transfers a methyl group from S-adenosylmethionine (SAM) to nitrogen N1 of nicotinamide to produce 1-methylnicotinamide (MNA) and S-adenosylhomocysteine. MNA is a messenger molecule that increases neurite branching, serves as an anti-thrombotic, and has anti-inflammatory properties.2,3,4 The role of NNMT overexpression in cancers may be to alter epigenetic methylation patterns in two ways: by lowering the intracellular concentration of SAM, required by methyltransferase enzymes, and by depleting the available NAD+ by transforming nicotinamide to MNA.4,5 Sirtuins use NAD+ as a substrate to alter protein acetylation and ribosylation, including histone targets.4 |
| 别名 | NNMT; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Alston, T.A. and Abeles, R.H. Substrate specificity of nicotinamide methyltransferase isolated from porcine liver. Archives of Biochemistry and Biophysics 260(2), 601-608 (1988). 2.Thomas, M.G.,Saldanha, M.,Mistry, R.J., et al. Nicotinamide N-methyltransferase expression in SH-SY5Y neuroblastoma and N27 mesencephalic neurones induces changes in cell morphology via ephrin-B2 and Akt signalling. Cell Death Dis. 4, e669 (2013). 3.Chlopicki, S.,Swies, J.,Mogielnicki, A., et al. 1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway. British Journal of Pharmacology 152(2), 230-239 (2007). 4.Shlomi, T. and Rabinowitz, J.D. Cancer mistunes methylation. Nature Chemical Biology 9(5), 293-294 (2013). 5.Ulanovskaya, O.A.,Zuhl, A.M. and Cravatt, B.F. NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink. Nature Chemical Biology 9(5), 300-306 (2013). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% estimated by SDS-PAGE |
| 稳定性 | ≥ 6 months |
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