| 货号 | 5349/10 |
| 别名 | 2-[[(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-H |
| 供应商 | Tocris |
| 生物活性 | Potent prostacyclin (PGI2) analog (EC50 values are 0.6, 1.9 and 6.2 nM at DP1, IP and EP2 receptors respectively). Causes vasodilation of human pulmonary arteries and inhibits NFκB nuclear translocation in human alveolar macrophages in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 390.51 |
| 分子式 | C23H34O5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
| 参考文献 | Whittleet al (2012) Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: treprostinil is a potent DP1 and EP2 agonist. Biochem.Pharmacol. 84 68. PMID: 22480736. Fontanaet al (2007) Treprostinil potentiates the positive inotropic effect of catecholamines in adult rat ventricular cardiomyocytes. Br.J.Pharmacol. 151 779. PMID: 17533419. Raychaudhuriet al (2002) The prostacyclin analogue treprostinil blocks NFκB nuclear translocation in human alveolar macrophages. J.Biol.Chem. 277 33344. PMID: 12082102. |