| 货号 | 2002/10 |
| 别名 | 3-[3-[2,5-Dihydro-4-(1-methyl-1H-in |
| 供应商 | Tocris |
| 生物活性 | Protein kinase C inhibitor, with activity at other protein kinases (IC50 values are 33, 3, 8, 15 and 38 nM for PKCα, MAPKAP-K1b, MSK1, GSK3β and S6K1 respectively). Activates JNK and glycogen synthase, and inhibits MAPK and ERK2, in rat adipocytes and L6 myotubes. Also inhibits voltage-dependent Na+ channels in the micromolar range. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >97 % |
| 计算分子量 | 553.65 |
| 分子式 | C25H23N5O2S.CH3SO3H |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 5 mM in ethanol |
| CAS号 | 125314-64-9 |
| 参考文献 | Davieset al (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem.J. 351 95. PMID: 10998351. Lingameneniet al (2000) Inhibition of voltage-dependent sodium channels by Ro 31-8220, a 'specific' protein kinase C inhibitor. FEBS Lett. 473 265. PMID: 10812087. Standaertet al (1999) RO 31-8220 activates c-Jun N-terminal kinase and glycogen synthase in rat adipocytes and L6 myotubes. Comparison to actions of insulin. Endocrinology 1502145. Daviset al (1989) Potent, selective inhibitors of protein kinase C. FEBS Lett. 259 61. PMID: 2532156. |