| 货号 | 2442/10 |
| 别名 | 5,6-bis[(4-Fluorophenyl)amino]-1H-i |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of PKCβII (IC50 values are 0.41 and 3.8 μM for PKCβII and PKCβI respectively). Also inhibits prionogenic Sup35 fibrillization (IC50 ~ 3.4 μM) and inhibits de novoAβ42 assembly in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 365.34 |
| 分子式 | C20H13F2N3O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in ethanol |
| CAS号 | 145915-60-2 |
| 参考文献 | Wanget al (2008) Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proc.Natl.Acad.Sci.USA 1057159. Kouroedovet al (2004) Selective inhibition of protein kinase Cβ2 prevents acute effects of high glucose on vascular cell adhesion molecule-1 expression in human endothelial cells. Circulation 110 91. PMID: 15210597. |