| 货号 | 5237/10U |
| 别名 | (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R |
| 供应商 | Tocris |
| 生物活性 | Protein kinase C (PKC) activator; analog of Bryostatin 1 (Cat. No. 2383). Attenuates cell proliferation and cell attachment in U937 cells. Inhibits DNA synthesis at 100 nM in SH-SY5Y human neuroblastoma cells. Also inhibits EGF binding and induces arachidonic acid release in vitro. Antitumor. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 863 |
| 分子式 | C45H66O16 |
| 可溶性/溶解性 | Soluble in ethanol |
| 参考文献 | Kedeiet al (2013) Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action. Biochem Pharmacol. 85 313. PMID: 23146662. Jalavaet al (1990) Effects of bryostatins 1 and 2 on morphological and functional differentiation of SH-SY5Y human neuroblastoma cells. Cancer Res. 50 3422. PMID: 2334938. Daleet al (1989) Comparison of effects of bryostatins 1 and 2 and 12-O-tetradecanoylphorbol-13-acetate on protein kinase C activity in A549 human lung carcinoma cells. Cancer Res. 49 3242. PMID: 2720677. Dell'Aquilaet al (1988) Differential effects of bryostatins and phorbol esters on arachidonic acid metabolite release and epidermal growth factor binding in C3H 10T1/2 cells. Cancer Res. 48 3702. PMID: 3132318. |