| 货号 | 5498/1 |
| 供应商 | Tocris |
| 生物活性 | High affinity, selective ANP clearance receptor (NPR3) antagonist (Ki = 0.45 nM). Exhibits >20,000-fold selectivity for NPR3 over NPR1. Inhibits ANP-stimulated Na+/K+ pump activity in rabbit ventricular cardiomyocytes in vitro. Also blocks proliferation of rodent neonatal cardiomyocytes seen at low ANP concentrations in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 915.1 |
| 分子式 | C46H66N12O8< |
| 可溶性/溶解性 | Soluble to 1 mg/ml in 10% ethanol / water |
| 序列号 | RIDR (Modifications: Arg-1 = N2-[4-(2-Naphthoylamino)phenyl |
| 参考文献 | Beckeret al (2014) Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development. Development 141 335. PMID: 24353062. Williamet al (2008) Natriuretic peptides stimulate the cardiac sodium pump via NPR-C-coupled NOS activation. Am.J.Physiol.Cell Physiol. 294 C1067. PMID: 18272821. Vealeet al (2000) The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1. Bioorg.Med.Chem.Lett. 10 1949. PMID: 10987424. |