| 货号 | 3882/10 |
| 别名 | (E)-3-Ferrocenylmethylidene-1,3-dih |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) (IC50 = 214 nM). Displays anticancer activity (IC50< 1 μM against B16 murine melanoma lines). Does not significantly inhibit VEGFR1 or PDGFRa or b at a concentration of 10μM. Geometric isomer of (Z)-FeCP-oxindole (Cat. No. 3883). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 计算分子量 | 329.17 |
| 分子式 | C19H15FeNO |
| 可溶性/溶解性 | Soluble to 5 mM in DMSO |
| 参考文献 | Spenceret al (2011) Synthesis and evaluation of metallocene containing methylene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors. Metallomics 3 600. PMID: 21359402. Spenceret al (2009) Structural and biological investigation of ferrocene-substituted 3-methylidene-1,3-dihydro-2H-indol-2-ones. Dalton Transact. 6918. |