货号 | 19602-250ug |
描述 | Cytostatin is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro(IC50s = 1.3 and 1.4 µg/ml, respectively) and B16 cells metastatic activity in mice.1,2 It induces apoptosis of FS3 mouse fibrosarcoma cells (IC50 = 3.1 µg/ml).3 Cytostatin potently and selectively inhibits protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), while having no effect against PP1, PP2B, or PP5.4,5 |
供应商 | Cayman |
应用文献 | |
1.Amemiya, M.,Ueno, M.,Osono, M., et al. Cytostatin, a novel inhibitor of cell adhesion to components of extracellular matrix produced by Streptomyces sp. MJ654-NF4. I. Taxonomy, fermentation, isolation and biological activities. J.Antibiot.(Tokyo) 47(5), 536-540 (1994). 2.Masuda, T.,Watanabe, S.-i.,Amemiya, M., et al. Inhibitory effect of cytostatin on spontaneous lung metastases of B16-BL6 melanoma cells. J. Antibiot. (Tokyo) 48(6), 528-529 (1995). 3.Yamazaki, K.,Amemiya, M.,Ishizuka, M., et al. Screening for apoptosis inducers in microbial products and induction of apoptosis by cytostatin. J.Antibiot.(Tokyo) 48(10), 1138-1140 (1995). 4.Kawada, M.,Amemiya, M.,Ishizuka, M., et al. Cytostatin, an inhibitor of cell adhesion to extracellular matrix, selectively inhibits protein phosphatase 2A. Biochim.Biophys.Acta. 1452(2), 209-217 (1999). 5.Swingle, M.R.,Amable, L.,Lawhorn, B.G., et al. Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and (β12-β13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors. J. Pharmacol. Exp. Ther. 331(1), 45-53 (2009). | |
运输条件 | Wet ice in continental US; may vary elsewhere |
存放说明 | -20 |
纯度 | ≥75% |
计算分子量 | 450.4 |
分子式 | C21H32O7P • Na |
CAS号 | 457070-06-3 |
稳定性 | ≥ 3 years |
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