| 货号 | 5727/10 |
| 别名 | 5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihyd |
| 供应商 | Tocris |
| 生物活性 | Potent class I and IIb HDAC inhibitor (IC50 values are 7, 20, 40, 100, 110 and 610 nM for HDAC6, HDAC3, HDAC10, HDAC1, HDAC2 and HDAC8, respectively). Suppresses proliferation and induces apoptosis of sarcoma cancer stem cells (CSCs) at concentrations >500 nM. Also induces osteogenesis in sarcoma CSCs at concentrations of 25 - 500 nM . |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 395.47 |
| 分子式 | C21H21N3O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Di Pompoet al (2015) Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells. J.Med.Chem. 58 4073. PMID: 25905694. Maiet al (2008) Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities. Bioorg.Med.Chem.Lett. 18 2530. PMID: 18381238. Maiet al (2006) Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors. J.Med.Chem. 49 6046. PMID: 17004718. |