| 货号 | 5792/100U |
| 供应商 | Tocris |
| 生物活性 | Potent Nav1.7 blocker (IC50 = 2.5 nM). Also inhibits Nav1.1, Nav1.2, Nav1.3 and Nav1.6 in the nanomolar range. Exhibits no effects on Cav channels or nAChR at 5 μM. Demonstrates analgesic activity in vivo; antagonizes effects of scorpion-venom toxin OD1 at Nav1.7. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 3802.41 |
| 分子式 | C162H246N52O |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | DCLKFGWKCNPRNDKCCSGLKCGSNHNWCK (Modifications: Disulfide bridge: 2-17, 9-22, 16-29, Ile-33 = C-terminal amide) |
| 参考文献 | Cardosoet al (2015) Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula thrixopelma pruriens. Mol.Pharmacol. 88 291. PMID: 25979003. |