| 货号 | 2174/10 |
| 别名 | 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6 |
| 供应商 | Tocris |
| 生物活性 | Partial positive allosteric modulator at the benzodiazepine receptor (IC50 = 1.3 μM for inhibition of flumazenil binding); natural sage flavone. Stimulates GABA-induced chloride currents in Xenopus oocytes expressing α1-,α2-,α3-,α5- or α6-β2γ2S GABAA receptors. Brain penetrant; oral administration reduces seizures in a gerbil model of epilepsy. Also has antifungal, antiproliferative, antioxidant and antithrombotic properties. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 300.27 |
| 分子式 | C16H12O6 |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO and to 10 mM in ethanol |
| CAS号 | 1447-88-7 |
| 参考文献 | Kavvadiaset al (2004) The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects. Br.J.Pharmacol. 142 811. PMID: 15231642. Kavvadiaset al (2003) Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor. Planta Med. 69 113. PMID: 12624814. Bourdillatet al (1988) Hispidulin, a natural flavone, inhibits human platelet aggregation by increasing cAMP levels. Eur.J.Pharmacol. 147 1. PMID: 2836213. |