GLPG 0974 ( )
货号：
5621/10 基本售价：
3410.6 元 规格：
10 mg
产品信息
概述| 货号 | 5621/10 |
| 别名 | 4-[[[(2R)-1-(Benzo[b]thien-3-ylcarbonyl)-2-methyl-2-azetidinyl]carbonyl][(3-chlorophenyl)methyl]amino]butanoic acid |
性能| 供应商 | Tocris |
| 生物活性 | Potent FFA2 antagonist (IC50 = 9 nM). Exhibits selectivity for FFA2 over FFA3. Inhibits acetate-induced human neutrophil migration in plasma or buffer. Also inhibits FFA2-induced expression of CD11b activation-specific epitope (AE) in human whole blood. Orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 485 |
| 分子式 | C25H25ClN2O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in 1eq. NaOH with gentle warming |
| 参考文献 | Pizzoneroet al (2014) Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic. J.Med.Chem. 57 10044. PMID: 25380412. |
