Centrinone B (10 MG)
货号：
5690/10 基本售价：
3410.6 元 规格：
10 mg
产品信息
概述| 货号 | 5690/10 |
| 别名 | 2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(1-piperidinyl)-4-pyrimidinamine; LCR 323 |
性能| 供应商 | Tocris |
| 生物活性 | High affinity and selective PLK4 inhibitor (Ki = 0.6 nM). Exhibits >2000-fold selectivity for PLK4 over Aurora A and Aurora B. Depletes centriole and centrosome levels in vitro. Induces cell cycle arrest in normal human cell lines in a p53-dependent manner. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 631.67 |
| 分子式 | C27H27F2N7 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| 参考文献 | Wonget al (2015) Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science 348 1155. PMID: 25931445. |
