| 货号 | 9843S |
| 供应商 | CST |
| 背景 | Geldanamycin (GA) is a naturally existing HSP90 inhibitor that belongs to the benzoquinone ansamycin family. GA binds to the amino terminal ATP-binding pocket of HSP90 and inhibits ATP binding and hydrolysis. HSP90 is a chaperone interacting with a wide variety of important target proteins for cell signaling and regulation during tumorgenesis (1,2). The binding of GA to HSP90 interferes with HSP-mediated target protein folding, leading to target aggregation and degradation (1-3). GA and its synthetic derivatives show higher affinity to HSP90 in tumor cells as compared to normal tissues and constitute a class of protential antitumor drugs (2-3). |
| 存放说明 | -20C |
| 参考文献 | Ochel, H.J. et al. (2001) Cell Stress Chaperones 6, 105-112. Sharp, S. and Workman, P. (2006) Adv.Cancer Res. 95, 323-348. Kamal, A. et al. (2003) Nature 425, 407-410. |
Western blot analysis of extracts from HEK293 cells, untreated or treated with indicated concentrations of Geldanamycin for 20 hours, using IKKα Antibody #2682 showing IKKα degradation (upper). β-Actin Antibody #4967 was used as a loading control (lower). 对HEK293细胞，不处理或加入所示浓度的Geldanamycin处理20小时，使用IKKα Antibody #2682进行Western blot分析，结果显示IKKα的降解（上图）。β-Actin Antibody #4967用作上样对照（下图）。 | |
Structure of Geldanamycin. Geldanamycin的结构。 |
