| 货号 | 15376-1mg |
| 描述 | Roquefortine C is a mycotoxin that was first isolated from a strain of P. roqueforti, a species of Penicillium commercially used to ripen blue-veined cheeses.1 It has also been isolated from other members of the Penicillium genus found in contaminated food products where it displays neurotoxic properties.2 It has been shown to both activate a P-glycoprotein transport system involved in the efflux of xenobiotics and to inhibit cytochrome P450 3A detoxification enzymes.3 It has also been used as a biomarker for penitrem A (Item No. 11347) intoxication.4 |
| 别名 | NSC 292134; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.García-Rico, R.O.,Chávez, R.,Fierro, F., et al. Effect of a heterotrimeric G protein alpha subunit on conidia germination, stress response, and roquefortine C production in Penicillium roqueforti. Int.Microbiol. 12(2), 123-129 (2009). 2.Richard, D.J.,Schiavi, B. and Joullié, M.M. Synthetic studies of roquefortine C: Synthesis of isoroquefortine C and a heterocycle. Proceedings of the National Academy of Sciences of the United States of America 101(33), 11971-11976 (2004). 3.Aninat, C.,André, F. and Delaforge, M. Oxidative metabolism by P450 and function coupling to efflux systems: modulation of mycotoxin toxicity. Food.Addit.Contam. 22(4), 361-368 (2005). 4.Tiwary, A.K.,Puschner, B. and Poppenga, R.H. Using roquefortine C as a biomarker for penitrem A intoxication. J.Vet.Diagn.Invest. 21(2), 237-239 (2009). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 389.5 |
| 分子式 | C22H23N5O2 |
| CAS号 | 58735-64-1 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |