| 货号 | 10310-100ug |
| 描述 | Cyclooxygenase metabolism of EPA to produce Prostaglandin E3(PGE3) has been reported in biosynthetic preparations of ovine seminal vesicles1 and in the ocular tissues of primates.2 Prostaglandin A3(PGA3) is an expected non-enzymatic dehydration product of this PGE3. PGA3 exhibits good affinity for the canine EP2 and EP4 receptors with IC50 values of 120 nM and 20 nM, respectively, in a radioligand binding assay.3,4PGA3 has weak affinity for human PPARγ, with a Ki value of 188 µM.5 |
| 别名 | PGA3; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lohmus, M.,Vahemets, A.,Järving, I., et al. Preparative separation of natural prostaglandins E. Preparative Chromatography 1, 279-300 (1991). 2.Kulkarni, P.S.,Kaufman, P.L. and Srinivasan, B.D. Eicosapentaenoic acid metabolism in cynomolgus and rhesus conjunctiva and eyelid. Journal of Ocular Pharmacology 3, 349-356 (1987). 3.Hibbs, T.A.,Lu, B.,Smock, S.L., et al. Molecular cloning and charcterization of the canine prostaglandin E receptor EP2 subtype. Prostaglandins & Other Lipid Mediators 57, 133-147 (1999). 4.Castleberry, T.A.,Lu, B.,Smock, S.L., et al. Molecular cloning and functional charcterization of the canine prostaglandin E2 receptor EP4 subtype. Prostaglandins & Other Lipid Mediators 65, 167-187 (2001). 5.Ferry, G.,Bruneau, V.,Beauverger, P., et al. Binding of prostaglandins to human PPARγ: Tool assessment and new natural ligands. European Journal of Pharmacology 417, 77-89 (2001). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 332.4 |
| 分子式 | C20H28O4 |
| CAS号 | 36614-31-0 |
| 稳定性 | ≥ 1 year |
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