| 货号 | 2163/1 |
| 别名 | Benzyloxycarbonyl-Val-Ala-Asp(OMe)- |
| 供应商 | Tocris |
| 生物活性 | Cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro(IC50 = 0.0015 - 5.8 mM). Active in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 467.49 |
| 分子式 | C22H30FN3O7 |
| 可溶性/溶解性 | Soluble to 9.35 mg/ml in DMSO |
| 序列号 | VAD (Modifications: Val-1 = Z-Val, Asp-3 = (OMe)-fluoromethylketone) |
| 参考文献 | Garcia-Calvoet al (1998) Inhibition of human caspases by peptide-based and macromolecular inhibitors. J.Biol.Chem. 273 32608. PMID: 9829999. Kinget al (1998) Processing/activation of caspases, -3 and -7 and -8 but not caspase-2, in the induction of apoptosis in B-chronic lyphocytic leukemia cells. Leukemia 12 1553. PMID: 9766499. Kunstleet al (1997) ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-α. Immunol.Lett. 55 5. PMID: 9093874. Sleeet al (1996) Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32. Biochem.J. 315 21. PMID: 8670109. |