| 货号 | 2900/10-TOCRIS |
| 别名 | (βR)-β-[[[(1S)-1-[[[(1S)-2-Methoxy-1- |
| 供应商 | Tocris |
| 生物活性 | Highly selective MMP-3 and MMP-12 inhibitor (IC50 values are 0.023, 0.042, 1.75, 2.3, 5.8, 30.4, 34.2 and 66.9 μM at MMP 3, 12, 8, 13, 7, 9, 2 and 14 respectively.) Inhibits fibronectin cleavage (IC50 = 320 nM) and has little effect on keratinocyte migration in vitro. Substantially inhibits MMP-3 in an ex vivo model of chronic dermal ulcers. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >95 % |
| 计算分子量 | 572.73 |
| 分子式 | C35H44N2O5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 25 mM in ethanol |
| CAS号 | 230961-21-4 |
| 参考文献 | Matthewset al (2008) Formulation, stability and thermal analysis of lypophilised wound healing wafers containing an insoluble MMP-3 inhibitor and a non-ionic surfactant. Int.J.Pharmaceutics 356110. Whitlocket al (2007) A novel series of highly selective inhibitors of MMP-3. Bioorg.Med.Chem.Letts. 176750. Frayet al (2003) A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic duodenal ulcers. J.Med.Chem. 46 3514. PMID: 12877590. |