| 货号 | 3032/1 |
| 别名 | N-[(1R)-1-[(4-Chlorophenyl)methyl]- |
| 供应商 | Tocris |
| 生物活性 | Potent and selective melanocortin 4 (MC4) receptor agonist (IC50 values are 1.2, 761 and 2067 nM for human MC4, MC3 and MC1 receptors respectively). Enhances intracavernosal pressure and stimulates erectile activity in rats ex copula following systemic administration. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >95 % |
| 计算分子量 | 589.17 |
| 分子式 | C33H41ClN6O2 |
| 可溶性/溶解性 | Soluble to 10 mM in water |
| CAS号 | 312637-48-2 |
| 参考文献 | Mutuliset al (2004) New substituted piperazines as ligands for melanocortin receptors. Correlation to the X-ray structure of "THIQ". J.Med.Chem. 47 4613. PMID: 15317471. Martinet al (2002) Activation of melanocortin MC4 receptors increases erectile activity in rats ex copula. Eur.J.Pharmacol. 454 71. PMID: 12409007. Sebhatet al (2002) Design and pharmacology of N-[(3R)-1,2,3,4-Tetrahydroisoquinolinium-3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)-2-[4-cyclohexyl-4-(1H-1,2,4-triazol-1-methyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective melanocortin subtype-4 receptor agonist. J.Med.Chem. 45 4589. PMID: 12361385. |