| 货号 | 4300/1 |
| 供应商 | Tocris |
| 生物活性 | CXCR4 antagonist and ACKR3 (CXCR7) agonist (EC50 = 350 nM for CXCR7). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 2066.43 |
| 分子式 | C90H140N34O1 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | RRACYXKXPYRXCR (Modifications: Disulfide bridge between 4 - 13, Arg-14 = C-terminal amide, Ala-3 = 3-(2-naphthalenyllalanine), X-6 and X-12 = L-Citrulline, X-8 = D-Citrulline) |
| 参考文献 | Gravelet al (2010) The peptidomimetic CXCR4 antagonist TC14012 recruits beta arrestin to CXCR7: roles of receptor domains. J.Biol.Chem. 285 37939. PMID: 20956518. Burgeret al (2005) Small peptide inhibitors of the CXCR4 chemokine receptor (CS184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells. Blood 106 1824. PMID: 15905192. Tamamuraet al (2003) Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives. Org.Biomol.Chem. 1 3656. PMID: 14649896. |