| 货号 | 3300/1 |
| 别名 | 2-[(1,2-Dihydro-2-oxo-3H-indol-3-yl |
| 供应商 | Tocris |
| 生物活性 | Potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μM at VEGFR2, FGFR1, PDGFRβ and EGFR respectively). Inhibits embryonic left-right determination and exhibits potent anticancer activity in vitroandin vivo. Also attenuates integrin β4-induced differentiation of neural stem cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >95 % |
| 计算分子量 | 296.32 |
| 分子式 | C17H16N2O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 215543-92-3 |
| 参考文献 | Suet al (2009) Neural stem cell differentiation is mediated by integrin beta4 in vitro. Int.J.Biochem.Cell Biol. 41 916. PMID: 18834954. Tanakaet al (2005) FGF-induced vesicular release of sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination. Nature 435 172. PMID: 15889083. Patersonet al (2004) Preclinical studies of fibroblast growth factor receptor 3 as a therapeutic target in multiple myeloma. Br.J.Haematol. 124 595. PMID: 14871245. Sunet al (1999) Design, synthesis and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF and PDGF receptor tyrosine kinases. J.Med.Chem. 42 5120. PMID: 10602697. |