| 货号 | 1806/10 |
| 别名 | 3,4-Dimethoxy-N-methyl-N-[3-[4-[[1- |
| 供应商 | Tocris |
| 生物活性 | Potent Ca2+ channel antagonist; binds allosterically to the a1-subunit of L-type Ca2+ channels (Kd = 20 pM), at a site distinct from other types of blocker. Shows some selectivity for vascular smooth muscle, inducing vasorelaxation without producing inotropic or chronotropic effects. Inhibits PDGF-stimulated smooth muscle cell proliferation. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 654.77 |
| 分子式 | C32H40N2O5S.C2H2O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 121346-32-5 |
| 参考文献 | Magnier-Gaubilet al (1996) Smooth muscle cell cycle and proliferation. Relationship between calcium influx and sarco-endoplasmic reticulum Ca2+ATPase regulation. J.Biol.Chem. 271 27788. PMID: 8910375. Romey and Lazdunski (1994) Effects of a new class of calcium antagonists, SR33557 (fantofarone) and SR33805, on neuronal voltage-activated Ca++ channels. J.Pharmacol.Exp.Ther. 271 1348. PMID: 7996445. Chatelainet al (1993) In vitro characterization of a novel Ca2+ entry blocker: SR 33805. Eur.J.Pharmacol. 246 181. PMID: 8223943. |