| 货号 | 4042/1 |
| 别名 | 6-[(2S,4R,6E)-4-methyl-2-(methylami |
| 供应商 | Tocris |
| 生物活性 | P-glycoprotein (P-gp) modulator; inhibits P-gp-mediated multidrug-resistance (MDR). Reverses resistance to several cytotoxic drugs including mitoxantrone and doxorubicin (resistance factors are 2.0 and 6.5 respectively) in human MDR cancer cell lines. Non-immunosuppressive analog of cyclosporin A (Cat. No. 1101). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 1214.62 |
| 分子式 | C63H111N11O12 |
| 可溶性/溶解性 | Soluble to 4 mM in DMSO |
| CAS号 | 121584-18-7 |
| 参考文献 | Shenet al (2009) Dynamic assessment of mitoxantrone resistance and modulation of multidrug resistance by Valspodar (PSC833) in multidrug resistance human cancer cells. J.Pharmacol.Exp.Ther. 330 423. PMID: 19423841. Shenet al (2008) Quantitation of doxorubicine uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells. J.Pharmacol.Exp.Ther. 324 95. PMID: 17947497. Godaet al (2007) Complete inhibition of P-glycoprotein by simulataneous treatment with a distinct class of modulators and the UIC2 monoclonal antibody. J.Pharmacol.Exp.Ther. 320 81. PMID: 17050779. Songet al (1998) Modulation of the tumor disposition of vinca alkaloids by PSC 833 in vitroandin vivo. J.Pharmacol.Exp.Ther. 287 963. PMID: 9864280. |