| 货号 | 3491/1 |
| 供应商 | Tocris |
| 生物活性 | Prion peptide fragment that shares many physiochemical features with PrPSc. Exhibits neurotoxicity caused by amplification of PrPC-associated signaling responses and induces NF-κB-mediated apoptosis in the mouse neuroblastoma cell line N2a. Forms β-sheet-rich, insoluble, protease-resistant fibrils and is used as a model to study prion diseases in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1912.26 |
| 分子式 | C80H138N26O24S2 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| CAS号 | 148439-49-0 |
| 序列号 | KTNMKHMAGAAAAGAVVGGLG |
| 参考文献 | Baiet al (2008) p75NTR activation of NF-κB is involved in PrP106-126-induced apoptosis in mouse neuroblastoma cells. Neurosci.Res. 62 9. PMID: 18602709. Pietriet al (2006) Overstimulation of PrPC signaling pathways by prion peptide 106-126 causes oxidative injury of bioaminergic neuronal cells. J.Biol.Chem. 281 28470. PMID: 16864581. Forloniet al (1993) Neurotoxicity of a prion protein fragment. Nature 362 543. PMID: 8464494. |