| 货号 | 1985/10 |
| 别名 | (1S)-1-[2-[4-[4-(Aminocarbonyl)phen |
| 供应商 | Tocris |
| 生物活性 | Very selective, high affinity 5-HT1D receptor agonist (Ki values are 6 and > 18000 nM at human 5-HT1D and 5-HT1B receptors respectively). Inhibits sympathetically-induced tachycardic responses and blocks neurogenic plasma protein extravasation in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 422.53 |
| 分子式 | C24H30N4O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 187665-65-2 |
| 参考文献 | Sanchez-Lopezet al (2003) Pharmacological profile of the 5-HT-induced inhibition of cardioaccelerator sympathetic outflow in pithed rats: correlation with 5-HT1 and putative 5-ht5A/5B receptors. Br.J.Pharmacol. 140 725. PMID: 14504136. McCallet al (2002) Preclinical studies characterizing the anti-migraine and cardiovascular effects of the selective 5-HT1D receptor agonist PNU-142633. Cephalalgia 22 799. PMID: 12485205. Roonet al (1999) Bovine isolated middle cerebral artery contractions to antimigraine drugs. Naunyn-Schmied.Arch.Pharmacol. 360591. |