| 货号 | 3785/10 |
| 别名 | 6-(2,6-Dichlorophenyl)-2-[[4-[2-(di |
| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of the tyrosine kinases c-Src, fibroblast growth factor receptor 1 (FGFR1), and platelet-derived growth factor receptor β(PDGFRβ) (IC50 values are 8.4, 39.3 and 98.3 nM respectively). Also inhibits the checkpoint kinases Wee1 and Myt1; abolishes Cdc2 phosphorylation in numerous tumor cell lines and abrogates the G2checkpoint. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 585.35 |
| 分子式 | C25H27Cl2N5O2.2HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 212391-63-4 |
| 参考文献 | Hashimotoet al (2006) Cell cycle regulation by the Wee1 inhibitor PD0166285, Pyrido [2,3-d] pyimidine, in the B16 mouse melanoma cell line. BMC Cancer 6 292. PMID: 17177986. Wanget al (2001) Radiosensitization of p53 mutant cells by PD0166285, a novel G2 checkpoint abrogator. Cancer Res. 61 8211. PMID: 11719452. Paneket al (1997) In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor. J.Pharmacol.Exp.Ther. 283 1433. PMID: 9400019. |