| 货号 | 4577/1 |
| 供应商 | Tocris |
| 生物活性 | Fluorescent ligand that binds to the α4β1 integrin (VLA-4) with high affinity (Kd values are 0.3 nM and 12 nM for binding to U937 cells in the presence and absence of Mn2+ respectively). Used to detect VLA-4 affinity and conformational changes. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1368.54 |
| 分子式 | C69H81N11O17 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in PBS (pH 7.4) |
| 序列号 | LDVPAAK (Modifications: Leu-1 N-2-[4-[[[(2-methylphenyl)amin |
| 参考文献 | Njuset al (2009) Conformational mAb as a tool for integrin ligand discovery. Assay Drug Dev.Technol. 7 507. PMID: 19754304. Chigaevet al (2003) FRET detection of cellular α4-integrin conformational activation. Biophys.J. 85 3951. PMID: 14645084. Chigaevet al (2001) Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn2+ or antibody activation. J.Biol.Chem. 276 48670. PMID: 11641394. |