| 货号 | 4717/10 |
| 别名 | (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,1 |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of Hedgehog signaling (IC50 = 500 - 700 nM); binds directly to Smoothened (Smo). Inhibits the response of target tissues to Sonic hedgehog signaling, possibly via the sterol sensing domain of Patched. Teratogenic. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 425.6 |
| 分子式 | C27H39NO3 |
| 可溶性/溶解性 | Soluble to 50 mM in ethanol and to 20 mM in DMSO |
| 参考文献 | Williamset al (2003) Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions. Proc.Natl.Acad.Sci.USA 100 4616. PMID: 12679522. ten Bergeet al(2001)Prx1andPrx2 are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis. Development 128 2929. PMID: 11532916. Cooperet al (1998) Teratogen-mediated inhibition of target tissue response to Shh signaling. Science 280 1603. PMID: 9616123. |