| 货号 | 4555/10 |
| 别名 | N-(12-Cyanoindolizino[2,3-b]quinoxa |
| 供应商 | Tocris |
| 生物活性 | T-LAK-cell-originated protein kinase (TOPK) inhibitor; exhibits selectivity for TOPK over other MAPKK family members including ERK1, JNK1 and p38. Blocks proliferation of HCT116 colon cancer cells; suppresses tumor growth in a colon cancer xenograft model. Also inhibits Chk1 (IC50 = 9.6 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 369.4 |
| 分子式 | C20H11N5OS |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Kimet al (2012) Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth. Cancer Res. 72 3060. PMID: 22523035. Liet al (2011) Discovery of novel checkpoint kinase 1 inhibitors by virtual screening based on multiple crystal structures. J.Chem.Inf.Model. 51 2904. PMID: 21955044. |