| 货号 | 2415/10 |
| 别名 | 1-[(1,2-Dihydro-1-oxo-5-isoquinolin |
| 供应商 | Tocris |
| 生物活性 | Cell-permeable active metabolite of Fasudil (HA 1077; Cat. No. 0541). Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 343.83 |
| 分子式 | C14H17N3O3S.HCl |
| 可溶性/溶解性 | Soluble to 20 mM in water |
| CAS号 | 105628-72-6 |
| 参考文献 | Utsunomiyaet al (2001) Antianginal effects of hydroxyfasudil, a Rho-kinase inhibitor, in a canine model of effort angina. Br.J.Pharmacol. 134 1724. PMID: 11739249. Shimokawaet al (1999) Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm. Cardiovasc.Res. 43 1029. PMID: 10615430. Araiet al (1993) Inhibition by the protein kinase inhibitor HA1077 of the activation of NADPH oxidase in human neutrophils. Biochem.Pharmacol. 46 1487. PMID: 8240400. |