| 货号 | 2285/10 |
| 别名 | 3-[1-[3-(Dimethylamino)propyl]-5-me |
| 供应商 | Tocris |
| 生物活性 | Broad spectrum protein kinase C (PKC) inhibitor (IC50 values are 7, 7, 6, 10, 60 and 20000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ and PKCμ respectively). Displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. Optimizes naïve human pluripotent stem cell growth and viability following naïve cell derivation from primed ESCs and iPSCs using naïve human stem cell medium (NHSM). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 442.51 |
| 分子式 | C26H26N4O3 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| CAS号 | 133053-19-7 |
| 参考文献 | Gafniet al (2013) Derivation of novel human ground state naive pluripotent stem cells. Nature 504 282. PMID: 24172903. Younget al (2005) Go 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury. Cardiovasc.Drug Rev. 23 255. PMID: 16252018. Petermanet al (2004) Go 6983 exerts cardioprotective effects in myocardial ischemic/reperfusion. J.Cardiovasc.Pharmacol. 43 645. PMID: 15071351. Gschwendtet al (1996) Inhibition of protein kinase C μ by various inhibitors. Differentiation from protein kinase c isozymes. FEBS Lett. 392 77. PMID: 8772178. |