| 货号 | 3201/10 |
| 别名 | 2,3,4,5-Tetrahydro-2,8-dimethyl-5-[ |
| 供应商 | Tocris |
| 生物活性 | Non-selective antihistamine that displays cognitive enhancing abilities. Also displays high affinity for 5-HT (particularly 5-HT6 and 5-HT7),α-adrenergic, dopaminergic, AMPA and NMDA receptors, and L-type calcium channels. Does not inhibit acetylcholinesterase activity. Exhibits neuroprotective activity in cellular models of Alzheimer's and Huntington's disease and preserves cognitive function following administration to AF64A lesioned rats. Protects neurons against the neurotoxic action of β-amyloid fragment; shown to enhance autophagy in yeast and reduce intracellular Aβ42 levels. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 392.37 |
| 分子式 | C21H25N3.2HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 100 mM in DMSO |
| CAS号 | 97657-92-6 |
| 参考文献 | Bharadwajet al (2012) Latrepirdine (Dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast. J.Alzheimers Dis. 32 949. PMID: 22903131. Giorgettiet al (2010) Cognition-enhancing properties of dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-methyl-D-aspartate receptor antagonism J.Pharm.Exp.Ther. 333748. Okunet al (2009) From anti-allergic to anti-Alzheimer's: molecular pharmacology of dimebon. Curr.Alzheimer Res. 797. Schaffhauseret al (2009) Dimebon is a 5-HT6 antagonist with acute cognitive enhancing activities. Biochem.Pharmacol. 78 1035. PMID: 19549510. Bachurinet al (2001) Antihistamine agent dimebon as a novel neuroprotector and a cognitive enhancer. Ann.N.Y.Acad.Sci. 939 425. PMID: 11462798. |