| 货号 | 1819/5 |
| 别名 | 2-[2-(1,1-Dimethyl-2-propenyl)-1H-i |
| 供应商 | Tocris |
| 生物活性 | Selective insulin receptor (IR) activator (EC50 values are 3 - 6 μM for IRTK and 100 μM for IGF1R and EGFR). Increases IR β subunit tyrosine phosphorylation and activation of PI 3-kinase and Akt, but not ERK. Induces glucose uptake in adipocytes and skeletal muscle in vitro, without enhancing vascular proliferation. Binds GAPDH. Also activates Trk by interacting at a site distinct from the neurotrophin-binding site. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 506.59 |
| 分子式 | C32H30N2O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 78860-34-1 |
| 参考文献 | Kimet al (2007) Glyceraldehyde 3-phosphate dehydrogenase is a cellular target of the insulin mimic demethylasterriquinone B1. J.Med.Chem. 50 3423. PMID: 17595071. Websteret al (2003) Signaling effects of demethylasterriquinone B1, a selective insulin receptor modulator. Chembiochem 4 379. PMID: 12740809. Salituroet al (2001) Discovery of a small molecule insulin receptor activator. Recent Prog.Horm.Res. 56 107. PMID: 11237209. Wilkieet al (2001) The non-peptidyl fungal metabolite L-783,281 activates TRK neurotrophin receptors. J.Neurochem. 78 1135. PMID: 11553687. Weberet al (2000) A novel insulin mimetic without a proliferative effect on vascular smooth muscle cells. J.Vasc.Surg. 32 1118. PMID: 11107083. |