| 货号 | 1571/1 |
| 别名 | (9β,10α,16α,23E)-2,16,20,25-Tetrahydro |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 514.65 |
| 分子式 | C30H42O7 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO and to 20 mM in ethanol |
| CAS号 | 2222-07-3 |
| 参考文献 | Dzienniset al (2007) Role of signal transducer and activator of transcription-3 in estradiol-mediated neuroprotection. J.Neurosci. 27 7268. PMID: 17611279. Nefedovaet al (2005) Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway. Cancer Res. 65 9525. PMID: 16230418. Blaskovichet al (2003) Discovery of JSI-124 (cucurbitacin I), a selective janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res. 63 1270. PMID: 12649187. |