| 货号 | 5130/1 |
| 供应商 | Tocris |
| 生物活性 | CXCR4 antagonist; induces mitotic catastrophe in ovarian cancer cells. Displays additive cytotoxic effects when given with taxol (Cat. No. 1097). Enhances the efficacy of docetaxel (Cat. No. 4056) in a mouse model. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1927.27 |
| 分子式 | C86H147N27O2 |
| 序列号 | KGVSLSYRK KGVSLSYR* (Modifications: Amide bridge = 9-8*, Lys-9 = C-terminal amide) |
| 参考文献 | Hassanet al (2011) CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model. Int.J.Cancer. 129 225. PMID: 20830712. Kwonget al (2009) An antagonist of the chemokine receptor CXCR4 induces mitotic catastrophe in ovarian cancer cells. Mol.Cancer Ther. 8 1893. PMID: 19567818. Faberet al (2007) The many facets of SDF-1alpha, CXCR4 agonists and antagonists on hematopoietic progenitor cells. J.Biomed.Biotechnol. 2007 26065. PMID: 17541466. |